Back to top

Alexandre Douplik, PhD

KHS 331B
Ryerson University
350 Victoria Street
Toronto, Ontario M5B 2K3
416-979-5000 x6538
douplik@ryerson.ca

Specialization

Biomedical Photonics

Research

Surface Enhanced and Near Field Optical Diagnostics and Therapy

  1. Development of Surface Enhanced Raman Fiber Probes for Optical Biopsy (Students: PhD student Aditya Pandya, BSc student Ermias Woldmichael)
  2. Near-field scalpel for Laser Surgery (Postdoc Olexandr Korovin from Max Plank Institute for the Science of Light, Erlangen, Germany)

Microsensor and Endoscopy Diagnostics

  1. Development of fiber sensor for in vivo real time monitoring of epithelium vessel/capillary spatial pattern alterations for diagnostics of shock development and cancer (Students: PhD student Irina Schelkanova, BSc student Graham Macdonald). The project is recently developed in cooperation with Kagishima University, Japan (Prof. Yasuyuki Kakihana), Prince Edward Island University, Canada (Prof. William Whelan)
  2. Adaptation of the fluorescence/narrow band endoscopy technology to microendoscopic applications: ductoscopy and angiography (Students: BSc students Lior Dubnitsky, Sam Peters, Sami Boubertakh). This project is currently developed with Profs Alexandra Easson, Wey Leong (University Health Network, Toronto), Prof. Susan Love (David Geffen School of Medicine at UCLA, Breast Cancer Research Foundation, USA), Prof. Paul J van Diest (University Medical Center Utrecht, Netherlands)
  3. Hyperspectral reflectance videoendoscopy for stomach cancer diagnostics (Students: PhD student Martin Hohmann). The project is recently developed with Prof. Michael Schmidt, Prof. Markus Neurath, Dr. Jonas Mudter (Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Germany)
  4. In vivo minimally invasive interstitial multi-functional microendoscope based on multicore fiber (Postdoc Asaf Shahmoon from Bar Ilan University in Ramat Gan, Israel). This project is currently developed in cooperation with Prof. Zeev Zalevsky (Electrical engineering and Nanophotonics at Bar Ilan University in Ramat Gan, Israel)
  5. Non-Invasive smartphone based blood cell counter (BSc student Abdulkarim Muhaseen)
  6. Remote invisible/ambient light monitoring of critical physiological parameters (Postdoc Guennadiy Sayko, BSc student Ruben Pinto). This project is developed in cooperation with Dr. Kipp Cannon (PERIMETER, Canada)

Optics and cognition interdisciplinary research: intelligent virtual interfaces for diagnostics and training

  1. Development of 3D video simulation setup to quantitatively assess and enhance the specific stereovision perception channel (PhD student Ian Paulus from FAU, Germany). This project is recently developed with Prof. Michael Schmidt, Prof. J. Hornegger, Prof. G. Michelson (Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Germany)
  2. Enhancement of the “lecturer-students” communication model via development of an interactively operated projection system equipped with gesture and voice recognition (Students: PhD student Aditya Pandya, BSc student Shivangi Rao)

Publications

Granted patents and inventions

1. A. Douplik, D. Adler, B. Wilson, N. Marcon “Method for Identifying benign and malignant lesions in Barrett’s esophagus using white light endoscopy”, US patent Serial No: US 12/572,473, Filed October 2, 2009 (http://www.freepatentsonline.com/20100087741.pdf).

2. A. Douplik, D. Adler, B. Wilson, N. Marcon “Method for Identifying malignancies in Barrett’s esophagus using white light endoscopy”, US patent Serial No: 61/102,091, Filed October 2, 2008.

3. V. Loschenov, A. Douplik, G. Vorozhtsov, Y. Ablitzov, E. Luk’yanetz “Method for suppressing cancer tumor growth”, Patent of Russian Federation Publication #2159644; (FIPS), Publication date 2000/11/27 (http://ru-patent.info/21/55-59/2159644.html).

4. V. Loschenov, A. Douplik, Vorozhtsov G.N., Y. Ablitzov, E. Luk’yanetz “Method for suppressing cancer tumor growth”, Patent of Russian Federation Publication #98113166; (FIPS), Publication date 2000/04/10.

5. V. Loschenov, A. Douplik, D. Klimov, K. Linkov “Method to prevent and cure diseases of the periodontium and mucous membrane of mouth”, Patent of Russian Federation Publication #97106366; (FIPS), Publication date 1999/04/20.

6. A.Y. Douplik, V.B. Loshchenov, M.T. Alexandrov “Flow through optical cuvette to examine liquid in hyperfine layers” Patent of Russian Federation Publication #2095787; (FIPS); Publication date 1997/11/10).

7. A.Y. Douplik, V.B. Loshchenov, M.T. Alexandrov “Flow through optical cuvette for optical studies” Patent of Russian Federation Publication #94037116; (FIPS); Publication date 1997/05/27.

Book Chapters

1. Alexandre Douplik, Alexander Stratonnikov, Olga Zhernovaya and Viktor Loschenov “Modifications of Blood Optical Properties during Photodynamic Reactions in Vitro and in Vivo”, Chapter 20 in “Advanced optical cytometry: methods and disease diagnoses”, Edited by V.V.Tuchin, Wiley-VCH, 2011 http://onlinelibrary.wiley.com/doi/10.1002/9783527634286.ch20/summary

2. Alexandre Douplik “Intraoperative OCT”, Chapter 25 in Handbook of Biophotonics, Edited by J.Popp, V.Tuchin, M.Strehle Wiley-VCH, 2010, 2011 http://www.wiley-vch.de/books/sample/3527410481_ftoc.pdf

3. Alexandre Douplik “OCT in urology”, Chapter 31 in Handbook of Biophotonics, Edited by J.Popp, V.Tuchin, M.Strehle Wiley-VCH, 2010, April 2011 http://www.wiley-vch.de/books/sample/3527410481_ftoc.pdf

4. Alexandre Douplik, Guennadi Saiko, Irina Schelkanova, Valery V. Tuchin „The response of tissue to laser light“ Chapter 2 in Lasers for medical applications, Edited by Helena Jelinkova, Woodhead Publishing, 2012 (http://www.woodheadpublishing.com/en/book.aspx?bookID=2476)

Peer-reviewed publications (Current Content, Last 4 years)

1. Guennadi Saiko, Alexandre Douplik, “Reflectivity of Biological Turbid Tissues Under Wide Area Illumination: Single Backward Scattering Approach“, accepted to International Journal of Photoenergy, Novel Photomedicine Issue, 2014

2. Homa Assadi, Rafii Karshafian, Alexandre Douplik, “Optical scattering properties of intralipid phantom in presence of encapsulated microbubbles“, accepted to International Journal of Photoenergy, Novel Photomedicine Issue, 2014

3. Arkady Rudnitsky, Asaf Shahmoon, Alexander Douplik, and Zeev Zalevsky, „Fiber endoscope with inflatable lens“, accepted to Optics Communications, In Press, Uncorrected Proof, Available online 24 December 2013 (http://www.sciencedirect.com/science/journal/aip/00304018)

4. Bay, E., Deán-Ben, X. L., Pang, G. A., Douplik, A. and Razansky, D. (2013), Real-time monitoring of incision profile during laser surgery using shock wave detection. J. Biophoton.. doi: 10.1002/jbio.201300151

5. Saiko, G.; Pandya, A.; Schelkanova, I.; Sturmer, M.; Beckert, R.J.; Douplik, A., "Optical Detection of a Capillary Grid Spatial Pattern in Epithelium by Spatially Resolved Diffuse Reflectance Probe: Monte Carlo Verification,"Selected Topics in Quantum Electronics, IEEE Journal of , vol.20, no.2, pp.1,9, March-April 2014, doi: 10.1109/JSTQE.2013. 2282278

6. Bay E., Douplik A., Ryazansky D., „Optoacoustic monitoring of cutting efficiency and thermal damage during laser ablation”, Lasers in Medical Science, [Epub ahead of print] doi:10.1007/s10103-013-1434-y, 2013

7. Shahmoon A., Aharon S., Kruchik O., Hohmann M., Slovin H., Douplik A. & Zalevsky Z., “In vivo minimally invasive interstitial multi-functional microendoscopy”, Nature Scientific Reports 3, Article number: 1805, doi:10.1038/srep01805, 2013

8. A. Douplik, W. l. Leong, A. Easson, S. Done, B. Wilson, A. Shahmoon, and Z. Zalevsky, Microendoscopic spectral imaging as a tool for small ductual diagnostics: preliminary experience, Journal of Innovative Optical Health Sciences (JIOHS), 05: 1250021 1-7 (2012)

9. Guennadi Saiko, Alexandre Douplik „Real-Time Optical Monitoring of Capillary Grid Spatial Pattern in Epithelium by Spatially Resolved Diffuse Reflectance Probe“, Innovative Optical Health Sciences (JIOHS), 05, 1250005 1-9 (2012)

10. Douplik, A., Zanati, S., Saiko, G., Streutker, C., Loshchenov, M., Adler, D., Cho, S., Chen, D., Cirocco, M., Marcon, N., Fengler, J. and Wilson, B. C. (2012), Diffuse reflectance spectroscopy in Barrett’s Esophagus: developing a large field-of-view screening method discriminating dysplasia from metaplasia. Journal of Biophotonics. doi: 10.1002/jbio.201200114 (http://onlinelibrary.wiley.com/doi/10.1002/jbio.201200114/abstract)

11. Ekaterina Krauss, Abbas Agaimy, Alexandre Douplik, Heinz Albrecht, Helmut Neumann, Arndt Hartmann, Ralf Hohenstein, Martin Raithel, Markus F. Neurath, Jonas Mudter Normalized Autofluorescence Imaging Diagnostics in Upper GI Tract: A New Method to Improve Specificity in Neoplasia Detection, International Journal of Clinical and Experimental Pathology, Int J Clin Exp Pathol. 2012; 5(9):956-64.

12. O. Sydoruk; O. Zhernovaya; V. Tuchin; A. Douplik, Refractive index of solutions of human hemoglobin from the near-infrared to the ultraviolet range: Kramers-Kronig analysis J. Biomed. Opt. 17 (11), 115002 (2012)

13. Korovin, A. Douplik, Prospective for creating a near-field scalpel for laser surgery, Optics Letters, Vol. 37 Issue 21, pp.4510-4512 (2012)

14. Florian Stelzle, Werner Adler, Azhar Zam, Katja Tangermann-Gerk, Christian Knipfer, Alexandre Douplik, Michael Schmidt and Emeka Nkenke, In Vivo Optical Tissue Differentiation by Diffuse Reflectance Spectroscopy: Preliminary Results for Tissue-Specific Laser Surgery SURG INNOV, vol. 19 no. 4, 385-393 (2012)

15. Florian Stelzle, Azhar Zam, Werner Adler, Katja Tangermann-Gerk, Alexandre Douplik, Emeka Nkenke and Michael Schmidt “Optical Nerve Detection by Diffuse Reflectance Spectroscopy for Feedback Controlled Oral and Maxillofacial Laser Surgery”, Journal of Translational Medicine, 09:20 (2011) (http://www.translational-medicine.com/content/9/1/20)

16. Zhernovaya O., Sidoruk O., Tuchin V., Douplik A., “The refractive index of human hemoglobin in the visible range”, Phys Med Biol. 56(13): 4013-21 (2011) (http://iopscience.iop.org/0031-9155/56/13/017)

17. Stelzle F., Tangermann-Gerk K., Adler W., Zam A., Schmidt M., Douplik A., Nkenke E., "Diffuse Reflectance Spectroscopy for Optical Soft Tissue Differentiation as Remote Feedback Control for Tissue-Specific Laser Surgery", Lasers in Surgery & Medicine, 42(4): 319-325 (2010) (http://onlinelibrary.wiley.com/doi/10.1002/lsm.20909/abstract).

18. Douplik A., Chen D., Akens M., Cirocco M., Bassett N., Marcon N., Fengler J. and Wilson B., "Assessment of Photobleaching During Endoscopic Autofluorescence Imaging of the Lower GI Tract," Lasers in Surgery and Medicine, Volume 42(3): 224-231 (2010) (http://onlinelibrary.wiley.com/doi/10.1002/lsm.20892/abstract).

19. Douplik A., Zam A., Hohenstein R., Kalitzeos A., Nkenke E., Stelzle F., "Limitations of Cancer Margin Delineation by Means of Autofluorescence Imaging under Conditions of Laser Surgery," Journal of Innovative Optical Health Sciences (JIOHS), Volume: 3, Issue: 1: 45-51, (2010) (http://www.worldscinet.com/jiohs/03/0301/S179354581000085X.html).

20. Douplik A., Leong W. L., Easson A. M., Done S., Netchev G., Wilson B. C., “A Feasibility Study of Autofluorescence Mammary Ductoscopy,” Journal of Biomedical Optics 14 (4), 044036 1-6, (2009) (http://spie.org/x648.html?product_id=848271

21. Lai B., Loshchenov M., Douplik A., Rusnov R., Jimenez-Davila M., Netchev G., Lilge L., “Three-Dimensional Fluence Rate Measurement and Data Acquisition System for Minimally Invasive Light Therapies,” Review of Scientific Instruments 80 (4), 43104.1-5, (2009) http://rsi.aip.org/resource/1/rsinak/v80/i4/p043104_s1

22. Rioux D., Laferrière M., Douplik A., Shah D., Lilge L., Kabashin A. V., Meunier M., “Silicon Nanoparticles Produced by Femtosecond Laser Ablation in Water as Novel Contamination-Free Photosensitizers,” Journal of Biomedical Optics 14 (2): 021010.1-5, (2009) http://spie.org/x648.html?product_id=830024

Other peer-reviewed publications (non-Current Content peer-reviewed journals, Last 4 years)

1. A. Shahmoon, A. Douplik, Z. Zalevsky “Micro-size multi-core fiber as an imaging tool for internal organ examination”, Physics Procedia 39 (2012) 830 – 834.

2. Alexandre Douplik, Wey L. Leong, Alexandra Easson, Susan J. Done, George Netchev and Brian C. Wilson “Preliminary experience of autofluorescence mammary ductoscopy“, Biomedical Optics and Medical Imaging SPIE newsroom, 24 October 2011, (http://spie.org/x57546.xml?highlight=x2416&ArticleID=x57546)

3. Alexandre Douplik, David Rioux, Marie Laferrière, Olga Zhernovaya, Lothar Lilge, Duoaud Shah, Michel M. Meunier, Andrei V. Kabashin “Photodynamic Therapy with Silicon Nanoparticles“, Photodiagnosis and Photodynamic Therapy, V. 8 (2): 207 (2011).

4. Douplik A., Zam A., Hohenstein R., Kalitzeos A., Nkenke E., Stelzle F., "Limitations of Cancer Margin Delineation by Means of Autofluorescence Imaging under Conditions of Laser Surgery," Journal of Innovative Optical Health Sciences (JIOHS), Volume: 3, Issue: 1: 45-51, (2010) (http://www.worldscinet.com/jiohs/03/0301/S179354581000085X.html).

5. Stelzle F., Zam A., Werner A., Douplik A., Tangermann-Gerk K., Nkenke, E., Neukam, F., Schmidt M., "Diffuse reflectance spectroscopy for optical nerve identification: Preliminary ex vivo results for feedback controlled oral and maxillofacial laser surgery." Physics Procedia 5 (Part 2): 647-654 (2010).

6. Douplik, A., "Combined surgery and photodynamic therapy of cancer." Physics Procedia 5 (Part 2): 641-645, (2010).

7. Zam A., Stelzle F., Tangermann-Gerk K., Werner A., Nkenke, E., Neukam, F., Schmidt M., Douplik A., "In vivo soft tissue differentiation by diffuse reflectance spectroscopy: preliminary results." Physics Procedia 5 (Part 2): 655-658 (2010).

8. Douplik A., “Photodynamic Therapy with nanoparticles.” Photodiagnosis and Photodynamic Therapy, V. 7, Suppl 1: 35 (2010).

Proceedings, Last 4 years

1. Bay E, Douplik A, Razansky D Optoacoustic monitoring of cutting and heating processes during laser ablation Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 8581; 85813X (2013), doi:10.1117/12.2005027

2. A. Douplik, “New generation of advanced microendoscopes”, Proceedings of Topical Problems of Biophotonics, Nizhny Novgorod, Russia, 21-27 July, 2013

3. A. Douplik, „Microendoscopy of small ducts as a potential tool for guiding and monitoring intruductual biopsy and therapy“, Proceedings of Canadian Assosiation of Physicists Congress, Physics in Canada, V. 67-2 (Supplement), W2-13, 2012.

4. A.Douplik, M. Hohmann, W. L. Leong, A. M. Easson, S. Done, H-G. Schaaf, B. C. Wilson, “Fluorescence microendoscopy of small ducts as a potential tool for guiding and monitoring laser intruductual surgery”, Proceedings of Conference of Laser Surgery and Medicine 2012 (CLSM 2012), April 26-27, 2012, Yokohama, Japan, pp. 40-41 (2012) (http://opicon.jp/wp-content/uploads/2012/03/CLSM2012-Program-Rev3.pdf).

5. A. Shahmoon, A. Douplik, Z. Zalevsky, “Multicore-fiber microendoscope as a potential tool for intravascular laser surgery guidance”, Proceedings of Conference of Laser Surgery and Medicine 2012 (CLSM 2012), April 26-27, 2012, Yokohama, Japan, pp. 60-61 (2012).

6. E. Bay, A. Douplik, and D. Razansky “Remote optoacoustic feedback for laser surgery”, Proceedings of Conference of Laser Surgery and Medicine 2012 (CLSM 2012), April 26-27, 2012, Yokohama, Japan, pp. 56-57 (2012).

7. O. Zhernovaya, V. Tuchin, A Douplik, “Multi-Wavelength Monitoring of the Real Part of Hemoglobin Refraction Index During Heating”, Proceedings of Conference of Laser Surgery and Medicine 2012 (CLSM 2012), April 26-27, 2012, Yokohama, Japan, pp. 58-59 (2012).

8. A. Douplik, W. L. Leong, A. M. Easson, S. Done, G. Netchev, B. C. Wilson, “Preliminary experience of autofluorescence mammary ductoscopy”, Proceedings of Topical Problems of Biophotonics, July 2011, St. Petersbourg-Nizhny Novgorod, Russia, 15-22 July, 2011 (http://www.biophotonics.sci-nnov.ru/biophotonics_11/img/Program-14jul.pdf).

9. Krauss E., Douplik A., Albrecht H., Agaimy A., Hohenstein R., Neurath M., Mudter J. “Normalized autoflluorescence imaging diagnostics in upper GI tract: a new method to improve specificity in neoplasia detection”, Gastroenterologie Viszeralchirurgie, Viszeralmedizin, 5. Herbsttagung der Deutschen Gesellschaft für Allgemein- und Viszeralchirurgie gemeinsam mit den Arbeitsgemeinschaften der DGAV P070: 228 (2011)(http://www.dgvs.de/media/Hauptprogramm_DGVS_final_neu.pdf).

10. Martin Hohmann, Alexandre Douplik, Janani Varadhachari, Aulia Nasution, Jonas Mudter, Markus Neurath, and Michael Schmidt “Preliminary results for hyperspectral videoendoscopy diagnostics on the phantoms of normal and abnormal tissues: towards gastrointestinal diagnostics”, Proc. SPIE 8087, 80872N (2011) (http://spie.org/x648.html?product_id=889829).

11. Jan Paulus, Joachim Hornegger, Michael Schmidt, Alexandre Douplik, Georg Michelson “A Polarized Dual-Projection System to Evaluate Stereo Vision”, Proc. of ARVO (The Association for Research in Vision and Ophthalmology, Inc.) Conference, 2011 (http://www.abstractsonline.com/plan/ViewAbstract.aspx?mID=2684&sKey=3c40...).

12. Rajesh Kanawade, Gennadi Sayko, Michael Schmidt, and Alexandre Douplik “In vivo monitoring of vessel density pattern in skin phantoms for the application of early sign of shock detection by using diffuse reflectance spectroscopy”, Proc. SPIE 7890, 789009 (2011) (http://spie.org/x648.html?product_id=874208).

13. Rajesh Kanawade, Gennadiy Saiko, Alexandre Douplik “Monitoring of the vessel capillary density spatial pattern in epithelium phantom model”, Proc. SPIE 7715, 771526 (2010) (http://spiedigitallibrary.org/proceedings/resource/2/psisdg/7715/1/771526_1).

14. Optical feedback and real time monitoring for laser surgery, Douplik A. Proc. Of International Symposium on Laser Medical Applications, Moscow, Russia, 5-6 of July 2010, p. 106.

15. Tissue differentiation by diffuse reflectance spectroscopy for automated oral and maxillofacial laser surgery: ex vivo pilot study, Zam A., Stelzle F., Tangermann-Gerk K., Adler W., Nkenke E., Schmidt M., Douplik A.,Proc. SPIE V7555, p. 16-1:6, 2010. (http://spiedigitallibrary.org/proceedings/resource/2/psisdg/7555/1/75551...).

16. Studies on the optical properties and reproducibility of agar- and resinstabilized tissue-like phantoms, Eisa F., Januts J., Pöschinger T., Perez A., Langenbucher A., Douplik A., 18th INTERNATIONAL LASER PHYSICS WORKSHOP Proceeding, Barcelona, 2009.

17. Tissue-Specific Laser Surgery: Hard Tissue Differentiation by Diffuse Reflectance Spectroscopy ex vivo, A. Zam, F. Stelzle, E. Nkenke, K. Tangermann-Gerk, M. Schmidt, W. Adler, and A. Douplik, in Frontiers in Optics, OSA Technical Digest (CD) (Optical Society of America, 2009), paper FThP2, 2009 (http://www.opticsinfobase.org/abstract.cfm?URI=FiO-2009-FThP2).

18. Enhancement of Cancerous/Normal Tissue Contrast via Combined White Light and Fluorescence Image Processing: Initial Investigation ex vivo, A. A. Kalitzeos, A. Zam, F. Stelzle, E. G. Hahn, M. Raithel, and A. Douplik, in Novel Optical Instrumentation for Biomedical Applications IV, C. Depeursinge and I. Vitkin, eds., Vol. 7371 of Proceedings of SPIE-OSA Biomedical Optics (Optical Society of America, 2009), paper 7371_0N, 2009 (http://www.opticsinfobase.org/abstract.cfm?URI=ECBO-2009-7371_0N).

19. Monitoring of Epithelial Capillary Density R. Kanawade, G. Saiko, and A. Douplik, in Novel Optical Instrumentation for Biomedical Applications IV, C. Depeursinge and I. Vitkin, eds., Vol. 7371 of Proceedings of SPIE-OSA Biomedical Optics (Optical Society of America, 2009), paper 7371_1L, 2009. (http://www.opticsinfobase.org/abstract.cfm?URI=ECBO-2009-7371_1).

20. Soft tissue differentiation by diffuse reflectance spectroscopy, A. Zam, F. Stelzle, E. Nkenke, K. Tangermann-Gerk, M. Schmidt, W. Adler, and A. Douplik, in Clinical and Biomedical Spectroscopy, I. Georgakoudi, J. Popp, and K. Svanberg, eds., Vol. 7368 of Proceedings of SPIE-OSA Biomedical Optics (Optical Society of America, 2009), paper 7368_21, 2009.
(http://www.opticsinfobase.org/abstract.cfm?URI=ECBO-2009-7368_21).