Biomedical Physics Seminars - Jan 30
Please join us for the Biomedical Physics Seminar Series.
TITLE: INVESTIGATION OF DUAL ENERGY CONE-BEAM COMPUTED TOMOGRAPHY FOR IMPROVEMENT OF SOFT TISSUE CONTRAST AND TUMOR DETECTION ON A RADIOSURGERY UNIT
Student: Vladimir Grouza
Supervisors: Dr. Mark Ruschin & Dr. James Grafe
ABSTRACT: Metastatic brain tumors occur secondary to 20-40% of all primary cancers. These are typically treated with stereotactic radiosurgery. However the current clinical workflow, which includes a planning MRI and a subsequent cone-beam computed tomography (CBCT) scan at the radiosurgery suite, is time consuming and error prone. More specifically, uncertainties in tumor position and volume introduced due to time between scans as well as coregistration of planning MRI and CBCT contribute to decreased precision in radiosurgical treatment. Consequently, we seek to improve soft-tissue contrast and tumor detection of the onboard CBCT by implementing dual energy (DE) scanning. We will pursue this aim by exploring DE basis material decomposition algorithms applied to real and simulated data, as well as on brain-tumor mimicking head phantom images acquired at the time of the arrival of the radiosurgical suite at Sunnybrook Health Sciences Centre.
TITLE: RADIOBIOLOGICAL ANALYSIS OF HIGH-DOSE RATE BRACHYTHERAPY FOR PROSTATE CANCER
Student: Julia Pearse
Supervisors: Dr. William Song & Dr. Carl Kumaradas
ABSTRACT: There are many radiobiological predictions for different radiation doses and fractionation schemes for prostate cancer. However, it is difficult to prove the efficacy of these predictions at time of treatment. My research focuses on prostate cancer patients who received high dose-rate brachytherapy five years ago, as well as a different cohort two years ago to try to come to a conclusion about what the ideal scheme for high dose-rate brachytherapy really is.