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Vladislav Toronov, PhD

KHS 333A
Ryerson University
350 Victoria Street
Toronto, Ontario M5B 2K3
416-979-5000 x4114
toronov@ryerson.ca

Specialization

  • Optical and Magnetic Resonance Biomedical Imaging
  • Non-Linear Dynamics of the Brain

Research

Brain is the most inscrutable arcana of modern science. Studies of the brain employ all basic and most of applied sciences. The progress in understanding of mechanisms is inseparable from the progress in method developments. I study brain from two perspectives of applied physics: experimental and theoretical. My theoretical studies focus on the development of casual models of neural processes and neurovascular coupling. My experimental research includes development of non-invasive functional imaging techniques and their combined use to measure various cerebral signals and to compare them with predictions of theoretical models.

Projects include:

  • Functional imaging of the human brain
  • Modeling of brain function
  • Development of diagnostic techniques for mild traumatic brain injury

Publications

Yeganeh, H., Toronov, V, Elliott, J, Diop, M, Lee, T-Y, St Lawrence, K, “Broadband continuous-wave technique to measure baseline values and changes in the tissue chromophore concentrations”, Biomedical Optics Express, Vol. 3 Issue 11, pp.2761-2770 (2012)

Schelkanova, I., Toronov, V., “Independent component analysis of broadband near-infrared spectroscopy data acquired on adult human head”, Biomedical Optics Express, 3, 64-74 (2012)

Wolf U., Toronov V., Choi J.H., Gupta R,. Michalos A., Gratton E, Wolf M., “Correlation of functional and resting state connectivity”, J. Biomed. Opt. 16, 087013 (2011)

Schelkanova, I., Toronov, V., “Optimal quantitation of the cerebral hemodynamic response in functional near-infrared spectroscopy”, Optics Express, 18, 9386-19395 (2010)

Pucci O., Toronov V., K. St. Lawerence, “Measurement of the optical properties of a two-layer model of the human head using broadband near-infrared spectroscopy”, Applied Optics, 49, 6324-6332 (2010)

O. Pucci, S. Stepanov, and V. Toronov, “Transcranial Near Infrared Spectroscopy of Smoking Brains”, J. Inn. Opt. Health Sci. 2, 227-234 (2009)

V. Toronov, X. Zhang, and A.G. Webb, "A spatial and temporal comparison of hemodynamic signals measured using optical and functional magnetic resonance imaging during activation in the human primary visual cortex", Neuroimage, 34, 1136-48 (2006).

X. Zhang, V. Toronov, and A. G. Webb, "An integrated measurement system for simultaneous functional magnetic resonance imaging and diffuse optical tomography in human brain mapping", Rev. Sci. Inst. 77, 114301 (2006).

Jacob M., Bresler Y., Toronov V., Zhang X, and Webb A., "A level-set algorithm for the reconstruction of functional activation in near-infrared spectroscopic imaging", J. Biomed. Opt. 11, 064029 (2006).

X. Zhang, V. Toronov, and A. G. Webb, "Simultaneous integrated diffuse optical tomography and functional magnetic resonance imaging of the human brain", Optics Express 13, 5518 (2005).

Choi J. H., Wolf M., Toronov V., Wolf U., Polzonetti C., Hueber D., Safonova L.P., Gupta R., Michalos A., Mantulin W., Gratton E, "Noninvasive determination of the optical properties of adult brain: near-infrared spectroscopy approach", J. Biomed. Opt. 9, 221 (2004).

Toronov, V., Webb, A., Walker, S., Gupta, R., Choi, J. H., Gratton, E., and Hueber, D., "The Roles of Changes in Deoxyhemoglobin Concentration and Blood Volume in the fMRI BOLD Signal", Neuroimage, 19, 1521-1531 (2003).

Wolf M., Wolf U., Choi J.H., Toronov V., Paunescu L.A, Michalos A., Gratton E., "Fast cerebral functional signal in the 100ms range detected in the visual cortex by frequency-domain near-infrared spectroscopy", Psychophysiology, 40, 521-528 (2003).