Basnagge Devika ChithraniBSc(First class honours, Colombo), MSc(Toronto), PhD(Toronto)
t. (250) 721-7702 f. (250) 721-7715
Medical physics, synthesis and characterization of nanoparticles, development of nanoparticle based systems for multimodal imaging and therapeutics, nanoparticle based radiosensitizers, drug delivery, intracellular fate of nanoparticles.
Nanotechnology involves creation and utilization of materials, devices or systems on the nanometer scale. The field of nanotechnology is currently undergoing explosive development on many fronts. Among other fields, nanotechnology is expected to generate innovations and play a critical role in the field of medicine. There has been tremendous progress made in the use of polymer and lipid based nanoparticles (NPs) for drug delivery and imaging. Recently, more attention has been given to incorporating inorganic NPs such as gold and magnetic NPs with both imaging and therapeutic capabilities into polymer and lipid based NPs for improved therapy and imaging in cancer treatment. In addition, this emerging field of nanomedicine requires better understanding of the interface between nanotechnology and medicine.
My research program is designed to improve the understanding of the bio-nano interface. Better knowledge of the nano-bio interface would lead to better tools for diagnostic imaging and therapy. As a step forward in this direction, gold nanoparticles are being used as a model platform for understanding how size, shape, and surface properties of nanoparticles (NPs) affect their intracellular fate. These fundamental studies will facilitate building of better NP-based platforms for improved results in the future cancer care of patients.
In treating cancer, radiation therapy and chemotherapy remain as the most widely used treatment options. Recent developments in cancer research show that the incorporation of gold nanostructures into those protocols have enhanced tumor cell damage. These nanostructures further provide strategies for improving loading, targeting, and controlling the release of drugs to minimize the side effects of highly toxic anticancer drugs used in chemotherapy and photodynamic therapy. In addition, the heat generation capability of gold nanostructures upon exposure to UV or near infrared is being used to damage tumor cells locally in photothermal therapy. My research program also involves the use of gold nanostructures as a versatile platform for integration of many therapeutic options towards optimizing combinational therapy platform in the battle against cancer. However, these platforms are still at the initial stage of development and much more research is required before they can be applied in clinical applications.
Here are some links to one my recent pod casts:
1. Darren Yohan, Charmainne Cruje, B. Devika Chithrani, Elucidating the Uptake and Distribution of Nanoparticles in Solid Tumors via a Multilayered Cell Culture Model,
Journal of Micro-Nano Letters (open access journal), 7, 127-137 (2015). Featured on the cover.
2. Celina Yang and B.D. Chithrani, Nuclear Targeting of gold nanoparticles, Review article, Journal of Medicinal Chemistry, In press (2015).
3. Mehrnoosh Neshatian, Stephen Chung, Darren Yohan, Celina Yang, B. Devika Chithrani, Uptake of Gold Nanoparticles in Breathless (hypoxic) Cancer Cells, Journal of Biomedical Nanotechnology, 11,1162-1172 (2015).
3. Celina Yang, Jamie Uertz, Darren Yohan, B. Devika Chithrani, Peptide Modified Gold Nanoparticles for Improved Cellular Uptake, Nuclear Transport, and Intracellular Retention, Nanoscale, 6, 12026-12033 (2014).
4. C. Cruje and B.D. Chithrani, Integration of Peptides for Enhanced Uptake of PEGylayed Gold Nanoparticles, Journal of Nanoscience and Nanotechnology, 15, 1-7 (2014).
5. C. Cruje and B.D. Chithrani, Polyethylene Glycol Density and Length Affects Nanoparticle Uptake by Cancer Cells, Journal of Nanomedicine Research, 1, 1-6 (2014).
6. Charmainne Cruje and B. Devika Chithrani, Polyethylene Glycol (PEG) Functionalized Nanoparticles for Improved Cancer Treatment, Reviews in Nanoscience and Nanotechnology, 3, 20-30 (2014).
7. M. Neshatian, S. Chung, D. Yohan, C. Yang, and B.D. Chithrani, Elucidating the Uptake of Nanoparticles in Tumor-like Environment (Hypoxic), Journal of Colloid and Interface Science Communications, 1, 57-61 (2014).
8. C. Yang, M. Neshatian, M. van Prooijen, and D. B. D. Chithrani, Cancer Nanotechnology: Enhanced Therapeutic Response Using Peptide-Modified Gold Nanoparticles, Journal of Nanoscience and Nanotechnology, 14, 4813–4819 (2014).
9. Darren Yohan and B. Devika Chithrani, Applications of Nanoparticles in Nanomedicine, Journal of Biomedical Nanotechnology, 10, 2371-2392 (2014).
10. C. Yang, D. Yohan and B.D. Chithrani, Optimized Bio-Nano Interface using Peptide Modified Colloidal Gold Nanoparticles, Journal of Colloid and Interface Science Communications, 1, 54-57 (2014).
11. B. Devika Chithrani, Use of Gold Nanoparticles as a Model System to Optimize Interface Between Medicine and Nanotechnology, Invited Review Article, Insciences, 1,115-135 (2011).
12. Salomeh Jelveh and B. Devika Chithrani, Gold-based Nanostructures for Improved Cancer Therapeutics, Invited Review Article, Cancers, 3, 1081 (2011).
13. B. Devika Chithrani, Intracellular uptake, transport, and excretion of nanoparticles, Invited Review Article, Molecular Membrane Biology, 27, 299-311,(2010).
14. B. Devika Chithrani, Nanoparticles for Improved Therapeutics and Imaging in Cancer Therapy, Invited Review Article, Recent Patents on Nanotechnology, 4, 171-180 (2010).
15. B. Devika Chithrani, Salomeh Jelveh, Richard P Hill, Robert Bristow, David A Jaffray, Gold Nanoparticles as a Radiation Sensitizer in Cancer Therapy, Radiation Research, 173, 719 (2010).
16. B. Devika Chithrani, James Stewart, Michael Dunne, Christine J. Allen, and David A. Jaffray, Cellular Uptake and Transport of Gold Nanoparticles in a Liposomal Carrier, Nanotechnology Biology, and Medicine 6,161(2010).
17. B. Devika Chithrani, James Stewart, Christine J. Allen, and David A. Jaffray, Intracellular Uptake and Transport of Nanostructures in Cancer Cells, Nanomedicine: Nanotechnology, Biology, and Medicine, 5, 118 (2009).
18. B. Devika Chithrani and Warren C.W. Chan, Elucidating the Mechanism of Cellular Uptake and Removal of Protein–coated Gold Nanoparticles of Different Sizes and Shapes, Nano Letters, 7, 1542 (2007).
19. B. Devika Chithrani, Arezou Ghazani, Warren C.W. Chan, Determining the Size and Shape Dependence of Nanoparticle – Uptake into Mammalian Cells, Nano Letters, 6, 662 (2006).
1. B. Devika Chithrani & Warren C.W. Chan, Photonics: A focused description of Gold Nanoparticles, Encyclopaedia of Biomedical Engineering, John Wiley & sons, Inc., May, 2006.
2. B. Devika Chithrani, Gold Nanoparticle-mediated Radiosensitization, Cancer Nanotechnology: Principles and Applications in Radiation Oncology, Taylor & Francis Inc., March 2013.
3. Mehrnoosh Neshatian, Celina Yang, Natasha Hegarty, & B. Devika Chithrani, Optimizing the Bio-Nano Interface for Gold Nanoparticle, Precious metals for Biomedical Applications, Woodhead Publishing, February 2014.
4. Charmaiine. Cruje, D. Yohan, C.Yang, M. Neshatian, and B.D. Chithrani, Intracellular behavior of nanoparticles based on their physico-chemical properties, Diverse Application of Nanotechnology in Biomedicine, Chemistry, and Engineering, IGI publishing, 2015.
Health Research Fund
NSERC Discovery Grant
Nanoscience and Technology Development Lab
Our group is very dynamic. We have one PhD student and two MSc students. Four MSc students have graduated from our group. Celina Yang is a PhD student and was featured at Ryerson today as one of exemplary students. The link is http://www.ryerson.ca/news/news/General_Public/20141015-biomed-student-m.... She joined our group with the math and biology background. She was able to excel in our medical physics program and published 3 papers and 4 proceedings during her MSc. One of her papers was published in Nanoscale journal.
Success of our previous graduate students:
Mehrnoosh Neshatian was able to publish two papers and a book chapter during her MSc and one of the papers was published in Biomedical Nanotechnology. It is the number 2 journal in Biomaterials.
Charmainne Cruje has published 2 papers, one review article, and a book chapter within a year into her MSc. She is our first CAMPEP graduate student. She is highlighted is Ryerson today. The link is as follows: http://ryerson.ca/science/newsevents/news/FirstCAMPEPgrad.html.
Darren Yohan has published one review article in Biomedical Nanotechnology and it the no.2 journal in Biomaterials. His first paper was featured on the cover of Nano-Micro Letters.
Current graduate Students:
Celina Yang: PhD student (http://www.ryerson.ca/news/news/General_Public/20141015-biomed-student-m...). She did her MSc in our group.
Previous graduate students:
Darren Yohan (His work is featured on the cover of Nano-Micro Letters, http://www.nmletters.org/, Volume 7, issue 2; Wrote a review article for Journal of Biomedical Nanotechnology, No.2 journal in Biomaterials)
Charmainne Cruje (http://ryerson.ca/science/newsevents/news/FirstCAMPEPgrad.html)
Mehrnoosh Neshatian (published two original articles and a book chapter, She published her work in Journal of Biomedical Nanotechnology, No.2 journal in Biomaterials)
Previous undergraduate students (4th year thesis)
Dr. Richard P Hill
Dr. Leon Sanche
Dr. Ian Tannock
Dr. Monique van Prooijen
Dr. Robert Bristow
An editorial board member : Journal of Reviews in Nanoscience and Nanotechnology
An editorial board member : International Journal of Theoretical and Applied Nanotechnology
An editorial board member : International Journal of Nano Studies and Technology
An editorial board member : Journal of Advanced Science, Engineering and Medicine An editorial board An editorial board member : Journal of Advances in Modern Oncology Research
Links to recent invited talk (on march 2nd):
Most Significant Contributions
1) B. Devika Chithrani, Salomeh Jelveh, Christine J Allen, Richard P Hill, Robert Bristow, David A Jaffray, Gold Nanoparticles as a Radiation Sensitizer in Cancer Therapy, Radiation Research, 173, 719 (2010). The paper is featured on the cover of the June issue of the Radiation Research Journal. This paper has received close to 140 citations.
2) B. Devika Chithrani and Warren C.W. Chan, Elucidating the Mechanism of Cellular Uptake and Removal of Protein-coated Gold Nanoparticles of Different Sizes and Shapes, Nano Letters, 7, 1542-1550 (2007). This paper was also featured as one of the most accessed articles by ACS publications. This paper has received over to 800 citations.
3) B. Devika Chithrani, Arezou Ghazani, Warren C.W. Chan, Determining the Size and Shape Dependence of Nanoparticle-Uptake into Mammalian Cells, Nano Letters, 6, 662-668 (2006). This paper is featured in Nanotech web, Faculty of 1000, Journal of Material today, and national cancer institute web site. ACS publication is declared this paper as one of the top 20 most cited articles. This paper has received close to 1800 citations.
4) D. Chithrani, R. L. Williams, J, Lefebvvre, P. J. Poole and G. C. Aers, Optical Spectroscopy of Single, Site-Selected InAs/InP Self-Assembled Quantum Dots, Appl. Phys. Lett. 84 (2004) 978. This paper has received over 80 citations.