Alexandre Douplik

Ph.D.
Associate Professor

Research Projects

Biospectroscopy for Clinical Diagnostics

1. Development of fiber sensor for in vivo real time monitoring of epithelium vessel/capillary spatial pattern alterations for diagnostics of shock development and cancer (recently being developed in cooperation with Kagishima University, Japan (Prof. Yasuyuki Kakihana), Prince Edward Island University, Canada (Prof. William Whelan)
2. Experimental spectroscopy study of the real part of the hemoglobin refraction index within the visible range depending on hemoglobin concentration, oxygenation and temperature confromations (recently being developed with Imperial College of London, UK (Dr. Olexiy Sydoruk) and Saratov University, Russia (Prof. V. Tuchin, Olga Zhernovaya)
3. Experimental and theoretical study of the Kramers-Kronig relationship between the real and imaginary parts of the refraction index of human hemoglobin (recently being developed with Imperial College of London, UK (Dr. Olexiy Sydoruk) and Saratov University, Russia (Prof. V. Tuchin, Olga Zhernovaya)
4. Experimental and theoretical study to develop a heuristic approach for fast estimation of the overall anisotropy factor (mean cosine of the scattering angle) of the mixture of different Mie-scatters (recently being developed with Oregon Medical Laser Centre, Oregon Health and Science University, USA (Prof. Scott Prahl)

Bioimaging for Cancer and Atherosclerotic Diagnostics

1. Adaptation of the fluorescence/narrow band endoscopy technology to microendoscopic applications: ductoscopy and angiography (recently being developed with Polydiagnost GmbH (Germany) (Hr. Hansgeorg Schaaf), David Geffen School of Medicine at UCLA, Breast Cancer Research Foundation, USA (Prof. Susan Love), University Medical Center Utrecht, Netherlands (Prof. Paul J van Diest)), LPT FAU (PhD candidate Martin Hohmann)
2. Hyperspectral reflectance videoendoscopy for stomach cancer diagnostics (recently being developed with e2v Technologies, UK (Dr Pritesh Mistry) and Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Germany (Prof. Markus Neurath, Dr. Jonas Mudter)

Laser Surgery Navigation and Monitoring

1. Autofluorescence navigation for cancer laser removal (recently being developed with Department of Oral and Maxillofacial Surgery, Universitätsklinikum Erlangen, Germany (Dr. med. Florian Stelzle, Dr. med. Dr. med. dent. Emeka Nkenke, Prof. Dr. med. Dr. med. dent. Friedrich Wilhelm Neukam), FAU (Dr. Ralph Hohenstein)
2. Optoacoustic monitoring of Laser Surgery (recently being developed with Technical University of Munich, Germany (Prof. Vasilis Ntziachristos, Dr. Daniel Razansky))
3. Exploration of a Sapphire Tip as Combined Mechanical/Contact Laser Cutter for Processing Inhomogeneous Soft Materials with Integrated Process Control (recently being developed with General Physics Institute of Russian Academy of Sciences (Prof. Victor Loschenov), Institute of Solid State Physics of Russian Academy of Science, Russia (Prof. Vladimir Kurlov)
4. Piezzoelectric monitoring of Laser Surgery (recently being developed with University of Aveiro, Portugal (Prof. Andrei Khlokin), Conway Institute of Biomolecular and Biomedical Research, Ireland (Prof. Brian J Rodriguez), FAU (Dr. Ilya Alexeev)

Photodynamic Therapy

1. Photosensitizer Doped Dental Composite Resins (recently being developed with University San-Paolo, Brasil (Prof. Dr. Alessandra Nara de Souza Rastelli), State Research Institute of Organic Semi-finished Products and Dyes, Russia (Prof. Euheniy Luk’yanetz))

Nanobiophotonics

1. Study of laser light interaction with nanosized gold centers in biological tissue (recently being developed with CNRS, Meditteranian University, France (Prof. Andrei Kabashin)
2. Development of Nanoparticle Magnetic-Photosensitizers complexes for Singlet Oxygen Photodynamic Therapy and Disinfection (recently being developed with FAU (Dr. Volodymir Lobaz, Prof. Wolgang Peukert)

Perception and reaction intelligent virtual training

1. Intelligent stimulators of specific channels of visual perception: improvement of Cyclopean 3D vision based on 3D video simulation setup (recently being developed with Interdisciplinary Center of Ophthalmic Preventive Medicine and Imaging, (Prof. G. Michelson), Optalmology Clinic (Prof. J. Kremers) of Universitätsklinikum Erlangen, Germany; FAU (Prof. J. Hornegger, Marc Stamminger, Prof. Michael Schmidt, PhD student Jan Paulus)

Selected Publications

Granted patents and inventions

1. A. Douplik, D. Adler, B. Wilson, N. Marcon “Method for Identifying benign and malignant lesions in Barrett’s esophagus using white light endoscopy”, US patent Serial No: US 12/572,473, Filed October 2, 2009 (http://www.freepatentsonline.com/20100087741.pdf).

2. A. Douplik, D. Adler, B. Wilson, N. Marcon “Method for Identifying malignancies in Barrett’s esophagus using white light endoscopy”, US patent Serial No: 61/102,091, Filed October 2, 2008.

3. V. Loschenov, A. Douplik, G. Vorozhtsov, Y. Ablitzov, E. Luk’yanetz “Method for suppressing cancer tumor growth”, Patent of Russian Federation Publication #2159644; (FIPS), Publication date 2000/11/27 (http://ru-patent.info/21/55-59/2159644.html).

4. V. Loschenov, A. Douplik, Vorozhtsov G.N., Y. Ablitzov, E. Luk’yanetz “Method for suppressing cancer tumor growth”, Patent of Russian Federation Publication #98113166; (FIPS), Publication date 2000/04/10.

5. V. Loschenov, A. Douplik, D. Klimov, K. Linkov “Method to prevent and cure diseases of the periodontium and mucous membrane of mouth”, Patent of Russian Federation Publication #97106366; (FIPS), Publication date 1999/04/20.

6. A.Y. Douplik, V.B. Loshchenov, M.T. Alexandrov “Flow through optical cuvette to examine liquid in hyperfine layers” Patent of Russian Federation Publication #2095787; (FIPS); Publication date 1997/11/10).

7. A.Y. Douplik, V.B. Loshchenov, M.T. Alexandrov “Flow through optical cuvette for optical studies” Patent of Russian Federation Publication #94037116; (FIPS); Publication date 1997/05/27.

Book Chapters (accepted)

1. Alexandre Douplik, Alexander Stratonnikov, Olga Zhernovaya and Viktor Loschenov “Modifications of Blood Optical Properties during Photodynamic Reactions in Vitro and in Vivo”, in “Advanced optical cytometry: methods and disease diagnoses”, Edited by V.V.Tuchin, Wiley-VCH, March 2011

2. Alexandre Douplik “Intraoperative OCT” in Handbook of Biophotonics, Edited by J.Popp, V.Tuchin, M.Strehle Wiley-VCH, 2010, April 2011.

3. Alexandre Douplik “OCT in urology” in Handbook of Biophotonics, Edited by J.Popp, V.Tuchin, M.Strehle Wiley-VCH, 2010, April 2011.

Peer-reviewed publications (Current Content)

1. Stelzle F., Tangermann-Gerk K., Adler W., Zam A., Schmidt M., Douplik A., Nkenke E., "Diffuse Reflectance Spectroscopy for Optical Soft Tissue Differentiation as Remote Feedback Control for Tissue-Specific Laser Surgery", Lasers in Surgery & Medicine, 42(4): 319-325 (2010) (http://onlinelibrary.wiley.com/doi/10.1002/lsm.20909/abstract).

2. Douplik A., Chen D., Akens M., Cirocco M., Bassett N., Marcon N., Fengler J. and Wilson B., "Assessment of Photobleaching During Endoscopic Autofluorescence Imaging of the Lower GI Tract," Lasers in Surgery and Medicine, Volume 42(3): 224-231 (2010) (http://onlinelibrary.wiley.com/doi/10.1002/lsm.20892/abstract).
Douplik A., Leong W. L., Easson A. M., Done S., Netchev G., Wilson B. C., “A Feasibility Study of Autofluorescence Mammary Ductoscopy,” Journal of Biomedical Optics 14 (4), 044036 1-6, (2009) (http://spie.org/x648.html?product_id=848271

3. Lai B., Loshchenov M., Douplik A., Rusnov R., Jimenez-Davila M., Netchev G., Lilge L., “Three-Dimensional Fluence Rate Measurement and Data Acquisition System for Minimally Invasive Light Therapies,” Review of Scientific Instruments 80 (4), 43104.1-5, (2009) http://rsi.aip.org/resource/1/rsinak/v80/i4/p043104_s1

4. Rioux D., Laferrière M., Douplik A., Shah D., Lilge L., Kabashin A. V., Meunier M., “Silicon Nanoparticles Produced by Femtosecond Laser Ablation in Water as Novel Contamination-Free Photosensitizers,” Journal of Biomedical Optics 14 (2): 021010.1-5, (2009) http://spie.org/x648.html?product_id=830024

5. Douplik A., Morofke D., Chiu S., Bouchelev V., Mao L., Yang V., Vitkin A., “In Vivo Real Time Monitoring of Vasoconstriction and Vasodilation by a Combined Diffuse Reflectance Spectroscopy and Doppler Optical Coherence Tomography Approach,” Lasers in Surgery and Medicine 40 (5), 323-331, (2008) http://onlinelibrary.wiley.com/doi/10.1002/lsm.20637/abstract

6. Zanati S.A., Marcon N.E., Cirocco M., Basset N., Streutker C., Kandel G.P., Kortan P.P., Rychel S., Douplik A., Wilson B., “Onco-LIFE Fluorescence Imaging during Colonoscopy Assists in the Differentiation of Adenomatous and Hyperplastic Polyps and Improves the Detection Rate of Dysplastic Lesions in the Colon,” Gastroenterology 128, A27-8, (2006).

7. Lilge L., Pomerleau-Dalcourt N., Douplik A., Selman S.H., Keck R.W., Szkudlarek M., Pestka M., Jankun J., “Transperineal in Vivo Fluence-Rate Dosimetry in the Canine Prostate During SnET2-Mediated PDT,” Physics in Medicine and Biology 49 (14), 3209-3225, (2004).

8. Jankun J., Lilge L., Douplik A., Keck R., Pestka M., Sykudlarek M., Stevens P.J., Lee R.J., Selman S.H., “Optical Characteristics of the Canine Prostate at 665 NM Sensitized with Tin Etiopurpurin Dichloride: Need for Real-Time Monitoring of Photodynamic Therapy,” Journal of Urology 172 (2), 739-743, (2004).

9. Stratonnikov A., Douplik A., Loschenov V., “Oxygen Consumption and Photobleaching in Whole Blood Incubated with Photosensitizer Induced by Laser Irradiation,” Laser Physics 13 (1), 1-21, (2003).

10. Douplik A.Y., Stratonnikov A.A., Loschenov V.B., Lebedeva V.S., Derkacheva V.M., Vitkin A., Rumyanceva V.D., Kusmin S.G., Mironov A.F., Luk’yanets E.A. “Study of Photodynamic Reactions in Human Blood,” J. of Biomed. Optics 5 (3), 338-349, (2000).

11. Stratonnikov A.A., Douplik A.Y., Loschenov V.B., “Oxygen Consumption and Its Transport in Tissues During Photodynamic Therapy of Tumors and Whole Blood,” Oxygen transport to tissues XXI, Ed. A. Eke and D.T. Delpy, Kluwer Academic/Plenum Publishers, NY, 515-524, (1999).

12. Stratonnikov A., Douplik A., Loschenov V. “Oxygen Consumption and its Transport in Tissues during Photodynamic Therapy of Tumors and Whole Blood”, Advances in Experimental Medicine and Biology 471, p. 515-523, (1999).

Peer-reviewed publications (Current Content, accepted)

1. Florian Stelzle, Azhar Zam, Werner Adler, Katja Tangermann-Gerk, Alexandre Douplik, Emeka Nkenke and Michael Schmidt “Optical Nerve Detection by Diffuse Reflectance Spectroscopy for Feedback Controlled Oral and Maxillofacial Laser Surgery”, accepted to Journal of Translational Medicine in April 2011

2. Zhernovaya O., Sidoruk O., Tuchin V., Douplik A., “The refractive index of human hemoglobin in the visible range”, accepted to Physics in Medicine and Biology in May 2011

Other peer-reviewed publications (non-Current Content peer-reviewed journals)

1. Alexandre Douplik, David Rioux, Marie Laferrière, Olga Zhernovaya, Lothar Lilge, Duoaud Shah, Michel M. Meunier, Andrei V. Kabashin “Photodynamic Therapy with Silicon Nanoparticles“, Photodiagnosis and Photodynamic Therapy, V. 8 (2): 207 (2011).

2. Douplik A., Zam A., Hohenstein R., Kalitzeos A., Nkenke E., Stelzle F., "Limitations of Cancer Margin Delineation by Means of Autofluorescence Imaging under Conditions of Laser Surgery," Journal of Innovative Optical Health Sciences (JIOHS), Volume: 3, Issue: 1: 45-51, (2010).

3. Stelzle F., Zam A., Werner A., Douplik A., Tangermann-Gerk K., Nkenke, E., Neukam, F., Schmidt M., "Diffuse reflectance spectroscopy for optical nerve identification: Preliminary ex vivo results for feedback controlled oral and maxillofacial laser surgery." Physics Procedia 5 (Part 2): 647-654 (2010).

4. Douplik, A., "Combined surgery and photodynamic therapy of cancer." Physics Procedia 5 (Part 2): 641-645, (2010).

5. Zam A., Stelzle F., Tangermann-Gerk K., Werner A., Nkenke, E., Neukam, F., Schmidt M., Douplik A., "In vivo soft tissue differentiation by diffuse reflectance spectroscopy: preliminary results." Physics Procedia 5 (Part 2): 655-658 (2010).

6. Douplik A., “Photodynamic Therapy with nanoparticles.” Photodiagnosis and Photodynamic Therapy, V. 7, Suppl 1: 35 (2010).

7. Vetshev P.S., Chilingaridi K.E., Ippolotov L.I., Kcharnas S.S., Loschenov V.B., Gabaidze D.I., Douplik A.Y., “The First Experience of the Laser Spectroscopy Application in Surgical Treatment of Thyroid Gland Diseases,” Problems of Endocrinology 1, 17 – 20, (1999).

8. Stratonnikov A., Loschenov V., Douplik A., Konov V. “The Control of Blood Oxygenation during Photodynamic Therapy in Biological Tissues and Blood”, Journal of Russian Chemistry, V. XLII, N5, p. 63-67, (1998) (in Russian).

9. Douplik A., Loschenov V. B., Stratonnikov A. A.,“Blood Oxygenation and Hemolysis Monitoring by Fiber Optic Spectrometer During Photodynamic Procedure in Vitro,” Medical & Biological Engineering & Computing 35, Suppl. P. I, B69-OS2.04, (1997).
10. Douplik A. “Dosimetry of Intravenous Laser Irradiation of Blood”, Laser-Market, N 2-3, p. 18-20, (1995).

Proceedings

1. Optical feedback and real time monitoring for laser surgery, Douplik A. Proc. Of International Symposium on Laser Medical Applications, Moscow, Russia, 5-6 of July, 2010, p. 106.

2. Tissue differentiation by diffuse reflectance spectroscopy for automated oral and maxillofacial laser surgery: ex vivo pilot study, Zam A., Stelzle F., Tangermann-Gerk K., Adler W., Nkenke E., Schmidt M., Douplik A.,Proc. SPIE V7555, p. 16-1:6, 2010. (http://spiedigitallibrary.org/proceedings/resource/2/psisdg/7555/1/75551...).

3. Studies on the optical properties and reproducibility of agar- and resinstabilized tissue-like phantoms, Eisa F., Januts J., Pöschinger T., Perez A., Langenbucher A., Douplik A., 18th INTERNATIONAL LASER PHYSICS WORKSHOP Proceeding, Barcelona, 2009.

4. Tissue-Specific Laser Surgery: Hard Tissue Differentiation by Diffuse Reflectance Spectroscopy ex vivo, A. Zam, F. Stelzle, E. Nkenke, K. Tangermann-Gerk, M. Schmidt, W. Adler, and A. Douplik, in Frontiers in Optics, OSA Technical Digest (CD) (Optical Society of America, 2009), paper FThP2, 2009. (http://www.opticsinfobase.org/abstract.cfm?URI=FiO-2009-FThP2).

5. Enhancement of Cancerous/Normal Tissue Contrast via Combined White Light and Fluorescence Image Processing: Initial Investigation ex vivo, A. A. Kalitzeos, A. Zam, F. Stelzle, E. G. Hahn, M. Raithel, and A. Douplik, in Novel Optical Instrumentation for Biomedical Applications IV, C. Depeursinge and I. Vitkin, eds., Vol. 7371 of Proceedings of SPIE-OSA Biomedical Optics (Optical Society of America, 2009), paper 7371_0N, 2009.
(http://www.opticsinfobase.org/abstract.cfm?URI=ECBO-2009-7371_0N).

6. Monitoring of Epithelial Capillary Density R. Kanawade, G. Saiko, and A. Douplik, in Novel Optical Instrumentation for Biomedical Applications IV, C. Depeursinge and I. Vitkin, eds., Vol. 7371 of Proceedings of SPIE-OSA Biomedical Optics (Optical Society of America, 2009), paper 7371_1L, 2009. (http://www.opticsinfobase.org/abstract.cfm?URI=ECBO-2009-7371_1).

7. Soft tissue differentiation by diffuse reflectance spectroscopy, A. Zam, F. Stelzle, E. Nkenke, K. Tangermann-Gerk, M. Schmidt, W. Adler, and A. Douplik, in Clinical and Biomedical Spectroscopy, I. Georgakoudi, J. Popp, and K. Svanberg, eds., Vol. 7368 of Proceedings of SPIE-OSA Biomedical Optics (Optical Society of America, 2009), paper 7368_21, 2009.
(http://www.opticsinfobase.org/abstract.cfm?URI=ECBO-2009-7368_21).

8. In vivo Real Time Combined Diffuse Reflectance-OCT Monitoring of Vasoconstriction and Vasodilation, A. Douplik, D. Morofke, S. Chiu, V. Bouchelev, L. Mao, V. Yang, and A. Vitkinin Biomedical Optics, OSA Technical Digest (CD) (Optical Society of America, 2008), paper BTuE8, 2008. (http://www.opticsinfobase.org/abstract.cfm?URI=BIOMED-2008-BTuE8).

9. Combined autofluorescence and white-light endoscopy for improved detection of dysplastic colonic lesions, A. Douplik, S. Zanati, N. Marcon, M. Cirocco, B. Wilson, J. Boehm, S. Rychel, and J. Fengler, inBiomedical Optics, Technical Digest (CD) (Optical Society of America, 2006), paper ME63, 2006. (http://www.opticsinfobase.org/abstract.cfm?URI=BIO-2006-ME63).

10. A method to improve the reproducibility of in vivo reflectance spectroscopy, Alexandre Douplik, David Shalaby, Brian C. Wilson, Joseph Perry, Proc. SPIE V5695, p. 335-339, 2005. (http://spiedigitallibrary.org/proceedings/resource/2/psisdg/5695/1/335_1...).

11. The spectral dependence of fiberoptic probe pressure on tissue during in vivo diffuse reflectance spectroscopy, Alexandre Douplik, David Shalaby, Brian Wilson in Biomedical Optics 2004 Technical Digest (Optical Society of America, Washington, DC, 2004), FG04, 2004. (http://www.opticsinfobase.org/abstract.cfm?URI=BIO-2004-FG4).

12. Integrating Cylinder for Calibration of Cylindrical Diffusers and Fluence and PO2 Sensors, Netchev G., Pomerleau N., Douplik A., Lilge L., SPIE VTD01, p.235-6, 2002.

13. New method of fluorescence diagnostics, photodynamic preventive maintenance, and treatment of diseases of the periodontium and mucous membrane of mouth, A.Y. Douplik, V. Loschenov, D. Klimov, K. Linkov, SPIE 3196, p. 206-209, 1998. (http://spie.org/x648.html?product_id=297934).

14. Oxygen consumption during photodynamic reactions in human blood, Alexandre Y. Douplik, Victor B. Loschenov, Victoria S. Lebedeva, Valentina M. Derkacheva, V. D. Rumyanceva, L. V. Chasovnikova, S. G. Kusmin, Andrei F. Mironov, Eugeny A. Lukyanets, V. I. Sergienko, Proc. SPIE V. 3254, p. 461-468, 1998. (http://spiedigitallibrary.org/proceedings/resource/2/psisdg/2979/1/378_1...).

15. Influence of light irradiation on blood oxygen saturation level in vitro and in vivo during photodynamic therapy, Alexander A. Stratonnikov, Alexandre Y. Douplik, D. V. Klimov, Victor B. Loschenov, S. V. Mizin, Proc. SPIE V. 3247, p. 128-136, 1998. (http://spiedigitallibrary.org/proceedings/resource/2/psisdg/3247/1/128_1...).

16. Noninvasive investigation of skin local hypothermia influence upon local oxygenation and hemoglobin concentration, A. Douplik, M. Kessler, Y. Kakihana, A. Krug, SPIE 2979, p. 375-377, 1997. (http://spiedigitallibrary.org/proceedings/resource/2/psisdg/2979/1/375_1...).

17. Stable and reliable measurement of intracapillary hemoglobin-oxygenation in human skin by EMPHO II, Yasuyuki Kakihana, Manfred D. Kessler, Alexandre Y. Douplik, Alfons Krug, SPIE 2979, p. 378-389, 1997. (http://spiedigitallibrary.org/proceedings/resource/2/psisdg/2979/1/378_1...).

18. Phenomenon of PDT-induced post irradiation apoptosis in biological liquids cancer cells using sulphonated aluminum photosensitizer, Douplik A.Yu., Loschenov V.B., Kogan E., Vorozhtsov G., Kusin M., Ablitsov Yu., Ilyina O, European Photobiology Society International Congress Proceeding, p. 123, Stressa, Italy, 1997.

19. Method of photodynamic prints as an investigation tool for study of photodynamic sessions in vitro, Douplik A., Loschenov V., European Photobiology Society International Congress Proceeding, p. 112, Stressa, Italy, 1997.

20. Phenomenon of PDT-induced post-irradiation apoptosis in biological liquids and cancer cells using sulphonated phtalocyanine aluminum photosensitizer, A. Y. Douplik, V. B. Loschenov, Voroztsov G., Kogan E., Kusin M., Ablitsov Y., Illyina O., SPIE 3191, p. 124-129, 1997. (http://spiedigitallibrary.org/proceedings/resource/2/psisdg/3191/1/124_1...).

21. Absorption spectroscopy as a tool to control blood oxygen saturation during photodynamic therapy, Alexander A. Stratonnikov, Alexandre Y. Douplik, D. V. Klimov, Victor B. Loschenov, Gennadii A. Meerovich, S. V. Mizin, Galina I. Fomina, Natalia I. Kazachkina, Raisa I. Yakubovskaya, Yu. V. Budenok, SPIE 3191, p. 58-66, 1997. (http://spiedigitallibrary.org/proceedings/resource/2/psisdg/3191/1/58_1?...).

22. Spectra changes of whole blood with sulphonated aluminum phtalocyanine photosensitizer during photodynamic therapy in vitro, Alexandre Y. Douplik, Victor B. Loschenov and Alexander A. Stratonnikov, Proc. SPIE 2923, 44, 1996. (http://spiedigitallibrary.org/proceedings/resource/2/psisdg/2923/1/44_1?...).

23. Identification of optical parameters of the whole blood depending on its oxygenation level, Douplik Alexandre, Loschenov Victor B., SPIE-Proc., Vol.2678, USA, 1996.

24. Changes of optical parameters of moving whole blood depending on shear rate, Alexandre Y. Douplik, Victor B. Loschenov, Vladislav G. Malinin, S. Proscurnev and D. V. Klimov, Proc. SPIE 2923, 35, 1996. (http://spiedigitallibrary.org/proceedings/resource/2/psisdg/2923/1/35_1?...).

25. Investigations of optical parameters changes of photosensitized whole blood during PDT, A. Y. Douplik, V. B. Loschenov, A. A. Stratonnikov, Abstracts of 12th international congress on Photobiology, p. 273, Vienna, 1996.

26. Optical parameters of moving whole blood, A. Douplik, Loschenov V., Klimov D., Abstracts of 12th international congress on Photobiology, p. 273, Vienna, 1996.

27. Laser fluorescence methods and equipment for Photodynamic Therapy and Optical Diagnostics of Cancer, A. Douplik, G. Meerovich, A. A. Stratonnikov V. Zuravleva, S. Misin, K. Linkov, D. Klimov, Abstracts of Russian Photobiology conference, Puschino, Russia (in Russian), p. 107, 1996.

28. Identification of spectroscopic and optical parameters of whole blood depending on its concentration and layer thickness, Douplik Alexandre, Loschenov V.B., SPIE-Proc., Vol. 2624, USA, p. 165-176, 1995 (http://spiedigitallibrary.org/proceedings/resource/2/psisdg/2326/1/319_1...).

29. Alexandre Y. Douplik and Anna M. Posypanova, Investigation of phtalocyanine Al photosensitizer and blood interaction, Nadezgda L. Torshina, Victor B. Loschenov, Alexander A. Stratonnikov, Proc. SPIE 2325, 389 (1995) (http://spiedigitallibrary.org/proceedings/resource/2/psisdg/2325/1/389_1...).

30. Use of the concept of “Specific Power Density of blood” for for parametrization of low-level laser irradiation” Douplick A.Y., SPIE-Proceeding Vol. 1981, p. 240-244, 1993 (http://spiedigitallibrary.org/proceedings/resource/2/psisdg/2086/1/308_1...).

31. Calculation of specific power density of blood for intravenous low-level laser therapy, Alexandre Y. Douplik, Y. N. Gordeev and Ilya V. Yaroslavsky, Proc. SPIE 1981, 240 (1993) (http://spiedigitallibrary.org/proceedings/resource/2/psisdg/1981/1/240_1...).

32. Calculation of the mean irradiation of blood for the intra-venous laser therapy, Douplik A., Gordeev Y., Yaroslavsky I., Contemporary status of the problem of laser technology application in clinical practice conference Proceeding, Russian State Medical University, Moscow, Russia (in Russian), P I, p. 87-89, 1992.

33. An optical determination method of the cryopreserved donor blood preparedness for the transfusion, Alexandrov M.T., Douplik A.Y., Contemporary status of the problem of laser technology application in clinical practice conference Proceeding, Russian State Medical University, Moscow, Russia (in Russian), P II, p. 178-180, 1992.

34. Optical transmission of human blood at 630, 850 and 960 nm, Douplik A.Y., Alexandrov M.T., Andreev E.M. Contemporary methods of optical monitoring during blood laser irradiation and clinical feedback of laser therapy efficacy conference Proceeding, Novosibirsk, Siberian Division of Russian Academy of Science, Russia (in Russian), p. 24-25, 1990.

35. Optical transmission of blood at 630 and 890 nm, Douplik A.Y., Actual Aspects of Laser Medicine Proceeding, Moscow Regional Research Hospital, Moscow, Russia (in Russian), p. 29-32, 1990.

Curriculum Vitae