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Colloquium - Applications of Time-Resolved NIRS to Neuromonitoring of Adult Critical-Care Patients

Monday, October 1, 2018 - 13:30
KHE 225

Presenter: Keith St Lawrence, PhD
University of Western Ontario, Dept of Medical Biophysics
Robarts Research Institute
Lawson Health Research Institute


Near-infrared spectroscopy has long been considered ideal for neuromonitoring given its sensitivity to tissue oxygenation, the measurements are non-invasive, and it is extremely safe. However, wider clinical acceptance of this technology has been hampered by its vulnerability to signal contamination from extracerebral tissues. I will present my research focused on enhancing the sensitivity to brain function by using time-resolved NIRS. This will include techniques my group have developed to assess key parameters of cerebral function and hemodynamics, as well as experiments performed to validate these methods for applications involving critical-care patients.

Keith St. Lawrence's Bio

A. Research Interests
My research is focused on developing quantitative imaging methods for studying brain function under normal and disease conditions. This covers multiple imaging modalities including optical techniques, magnetic resonance imaging and positron emission tomography. This has led to the development of portable optical devices for monitoring cerebral blood flow and oxygen utilization in intensive care patients. Another active research area is the adaptation of perfusion MRI to studying longitudinal changes in brain function. We have applied this technology in combination with other MRI techniques to the study of chronic pain, frontotemporal dementia, and cardiovascular disease. Finally, my group is investigating how the unique combination of PET/MRI can be harnessed for neuroimaging applications. We have developed a truly hybrid non-invasive approach for imaging brain perfusion, which we are extending to mapping cerebral oxygen consumption. We are also actively combining functional MRI with PET molecular imaging to better understand how brain function is altered by changes in underlying neurochemistry/physiology, including neuroinflammation.

B. Honours
• Heart and Stroke Foundation Mid-Career Investigator Award 2013-17
• SickKids Foundation New Investigator Award 2006-2008
• Fogarty International Fellowship, National Institutes of Health, January 1998 – October 2002
• Fellows Award for Research Excellence from the National Institutes of Health, 1999
• Medical Research Council of Canada Studentship, 1992-94
• National Science and Engineering Research Council Postgraduate Scholarship, 1988-89 and 1989-90
• The University of Winnipeg Gold Medal in Physics, 1988