Presenter: Sergio Fantini
Department of Biomedical Engineering, Tufts University
Member of the College of Fellows of the American Institute for Medical and Biological Engineering (AIMBE)
"Coherent hemodynamics spectroscopy for non-invasive optical assessment of brain perfusion"
Near-infrared spectroscopy (NIRS) and functional near-infrared spectroscopy (fNIRS) are non-invasive optical techniques for the study of cerebral hemodynamics and brain activation. Dynamic NIRS measurements have been proposed to monitor spontaneous hemodynamic oscillations that occur on a broad frequency range that span the scales from 0.001 Hz to 1 Hz. We have recently introduced a mathematical model that relates the measurable quantities with NIRS (namely the tissue concentrations of oxy- and deoxyhemoglobin) to the underlying physiological changes in cerebral blood volume (CBV), cerebral blood flow (CBF), and cerebral metabolic rate of oxygen (CMRO2). Furthermore, we have proposed to introduce periodic perturbations in the systemic mean arterial pressure (MAP) to induce associated cerebral hemodynamic responses at controlled frequencies. The analysis of such cerebral hemodynamic oscillations with our mathematical model results in the technique of coherent hemodynamics spectroscopy (CHS), which can measure cerebral perfusion, cerebral autoregulation, and quantify the frequency dependence of the MAP-CBV relationship.
Sergio Fantini is Professor of Biomedical Engineering and principal investigator of the “Diffuse Optical Imaging of Tissue Laboratory” (DOIT Lab) at Tufts University. The research in the DOIT Lab aims to develop non-invasive applications of diffuse optics to assess cerebral perfusion, detect breast cancer, and quantify skeletal muscle oxygenation. His research resulted in eleven patents and about two hundred scientific publications. He co-authored with Prof. Irving Bigio (Boston University) a textbook on “Quantitative Biomedical Optics” for Cambridge University Press. Prof. Fantini is Fellow of OSA, SPIE, and AIMBE.
The textbook "Quantitative biomedical optics : theory, methods, and applications" is available at Ryerson's Library: