Presenter: Dana Wegierak
Ryerson University, 2020
Master of Science, Biomedical Physics
Supervisor: Dr. Michael Kolios
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Dyed nano-sized bubbles have recently been proposed as contrast agents for multimodal US-PA imaging. However, changes to the shell composition due to the presence of the dye of a nanobubble can modify the response of bubbles to ultrasound. In this work, the effects of Sudan Black B on a fomulation of lipid shelled nanobubbles are studied. Formulations were produced with increasing concentration of Sudan Black B. The size and concentration of activated bubbles were tested. The surface tension of bulk lipid solution was measured using pendant drop tensiometry and activated bubble solutions were measured for single bubble and bubble population response to incident ultrasound. While results show no statistically significant effect of Sudan Black concentration on bubble concentration or size, sur face tension increased linearly with dye concentration to a maximum increase of 13%. Single bubble experiments show an increase in bubble dissolution and bubble growth signals with the addition of Sudan Black. The results presented in this work indicate that the presence of Sudan Black B in the lipid shell of a nanobubble may increase the shell permeability impacting stability of the bubble population and their potential for multimodal US-PA imaging.