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Catherine Beauchemin, PhD

Professor

KHS 331
Ryerson University
350 Victoria Street
Toronto, ON M5B 2K3
416-979-5000 x2508
cbeau@ryerson.ca

Specialization

Virophysics: use of physical models to resolve the temporal and spatial dynamics of viral infections. Specifically, the development of realistic mathematical and computer models to capture and expalin the kinetics of virus infection spread within a cell culture (in vitro) or a host (in vivo). Apply physical models to accurately quantify the mode of action and efficacy of antiviral drugs and the phenotypic effect of virus mutations which confer drug resistance. Virus of primary interest: influenza, hepatitis C, dengue, and the respiratory syncitial virus.

Research

The phymbie research group has many ongoing projects. Visit the phymbie website for more details about projects and opened positions. You might also want to watch this short video...

Recent Publications

AWC Yan, J Zhou, CAA Beauchemin, CA Russell, WS Barclay, S Riley. Cellular reproduction number, generation time and growth rate differ between human- and avian-adapted influenza strains. arXiv:1903.08054, March 2019. [arXiv:1903.08054]

Beauchemin, CAA, YI Kim, Q Yu, G Ciaramella, JP DeVincenzo. Uncovering critical properties of the human respiratory syncytial virus by combining in vitro assays and in silico analyses. PLoS ONE, 14(4):e0214708, 2019. doi:10.1371/journal.pone.0214708

Beauchemin, CAA, LE Liao, and K Blahut. Tutorial on agent-based models in NetLogo applied to immunology and virology. arXiv:1808.09499, August 2018. [arXiv:1808.09499]

Handel, A, LE Liao, and CAA Beauchemin. Progress and trends in mathematical modelling of influenza A virus infections. Curr. Opin. Syst. Biol., 12:30-36, 2018. doi:10.1016/j.coisb.2018.08.009

Rose, LM, CAA Beauchemin, and WP Neumann. Modelling endurance and resumption times for repetitive one-hand pushing. Ergonomics, 61(7):891-901, 2018. doi:10.1080/00140139.2018.1427282

Liao, LE, S Kowal, DA Cardenas, and CAA Beauchemin. Exploring virus release as a bottleneck for the spread of influenza A virus infection in vitro and the implications for antiviral therapy with neuraminidase inhibitors. PLoS ONE, 12(8):e0183621, 2017. doi:10.1371/journal.pone.0183621

Dobrovolny, HM and CAA Beauchemin. Modelling the emergence of influenza drug resistance: The roles of surface proteins, the immune response, and antiviral mechanisms. PLoS ONE, 12(7):e0180582, 2017. doi:10.1371/journal.pone.0180582

Beauchemin, CAA, T. Miura, and S. Iwami. Duration of SHIV production by infected cells is not exponentially distributed: Implications for estimates of infection parameters and antiviral efficacy. Sci. Rep., 7:42765, 2017. doi:10.1038/srep42765

Palmer, J, HM Dobrovolny, and CAA Beauchemin. The in vivo efficacy of neuraminidase inhibitors cannot be determined from the decay rates of influenza viral titers observed in treated patients. Sci. Rep., 7:40210, 2017. doi:10.1038/srep40210

Liao, LE, S Iwami, and CAA Beauchemin. (In)validating experimentally derived knowledge about influenza A defective interfering particles. J. R. Soc. Interface, 13(124):20160412, 2016. doi:10.1098/rsif.2016.0412

Lipsitch, M, W Barclay, R Raman, CJ Russell, JA Belser, S Cobey, PM Kasson, JO Lloyd-Smith, S Maurer-Stroh, S Riley, CAA Beauchemin, T Bedford, TC Friedrich, A Handel, S Herfst, PR Murcia, B Roche, CO Wilke, and CA Russell. Viral factors in influenza pandemic risk assessment. eLife, 5:e18491, 2016. doi:10.7554/eLife.18491

Simon, PF, MA de La Vega, E Paradis, E Mendoza, KM Coombs, D Kobasa, and CAA Beauchemin. Avian influenza viruses that cause highly virulent infections in humans exhibit distinct replicative properties in contrast to human H1N1 viruses. Sci. Rep., 6:24154, 2016. doi:10.1038/srep24154

Kamal, MA, R Gieschke, A Lemenuel-Diot, CAA Beauchemin, PF Smith, and CR Rayner. A drug-disease model decribing the effect of oseltamivir neuraminidase inhibition on influenza virus progression. Antimicrob. Agents Chemother., 59(9):5388-5395, 2015. doi:10.1128/AAC.00069-15

Kakizoe, Y, S Morita, S Nakaoka, Y Takeuchi, K Sato, T Miura, CAA Beauchemin, and S Iwami. A conservation law for virus infection in vitro. J. Theor. Biol., 376:39-47, 2015. doi:10.1016/j.jtbi.2015.03.034

Kakizoe, Y, S Nakaoka, CAA Beauchemin, S Morita, H Mori, T Igarashi, K Aihara, T Miura, and S Iwami. A method to determine the duration of the eclipse phase for in vitro infection with a highly pathogenic simian human immunodeficiency virus strain. Sci. Rep., 5:10371, 2015. doi:10.1038/srep10371

Paradis, EG, LT Pinilla, BP Holder, Y Abed, G Boivin, and CAA Beauchemin. Impact of the H275Y and I223V mutations in the neuraminidase of the 2009 pandemic influenza virus in vitro and evaluating experimental reproducibility.. PLoS ONE, 10(5):e0126115, 2015. doi:10.1371/journal.pone.0126115